Nifedipine Induces Peroxisome Proliferator-Activated Receptor-γ Activation in Macrophages and Suppresses the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
Author(s) -
Norio Ishii,
Takeshi Matsumura,
Hiroyuki Kinoshita,
Kazuki Fukuda,
Hiroyuki Motoshima,
Takafumi Senokuchi,
Saya Nakao,
Atsuyuki Tsutsumi,
Shokei KimMitsuyama,
Teruo Kawada,
Motohiro Takeya,
Nobuhiro Miyamura,
Takeshi Nishikawa,
Eiichi Araki
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.202309
Subject(s) - nifedipine , peroxisome proliferator activated receptor , endocrinology , medicine , phosphorylation , calcium channel , kinase , extracellular , biology , pharmacology , receptor , calcium , microbiology and biotechnology , biochemistry
Nifedipine, an L-type calcium channel blocker, protects against the progression of atherosclerosis. We investigated the molecular basis of the antiatherosclerotic effect of nifedipine in macrophages and apolipoprotein E-deficient mice.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom