Open AccessEnhanced Abdominal Aortic Aneurysm Formation in Thrombin-Activatable Procarboxypeptidase B–Deficient Mice
Author(s) -
Geoffrey M. Schultz,
Maureen M. Tedesco,
Eiketsu Sho,
Toshihiko Nishimura,
Shadi Sharif,
Xiaoyan Du,
Timothy Myles,
John Morser,
Ronald L. Dalman,
Lawrence Leung
Publication year - 2010
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.202259
Subject(s) - thrombomodulin , plasmin , osteopontin , thrombin , abdominal aortic aneurysm , inflammation , chemistry , pharmacology , medicine , immunology , aneurysm , biochemistry , platelet , surgery , enzyme
To determine whether procarboxypeptidase B (pCPB)(-/-) mice are susceptible to accelerated abdominal aortic aneurysm (AAA) development secondary to unregulated OPN-mediated mural inflammation in the absence of CPB inhibition.
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