PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure | Zendy

Ruby C.Y. Lin | Zendy; Kate L. Weeks | Zendy; XiaoMing Gao | Zendy; Rohan B. H. Williams | Zendy; Bianca C. Bernardo | Zendy; Helen Kiriazis | Zendy; Vance B. Matthews | Zendy; Elizabeth A. Woodcock | Zendy; Russell D. Bouwman | Zendy; Janelle P. Mollica | Zendy; H. J. L. Speirs | Zendy; Ian W. Dawes | Zendy; Roger J. Daly | Zendy; Tetsuo Shioi | Zendy; Seigo Izumo | Zendy; Mark A. Febbraio | Zendy; XiaoJun Du | Zendy; Julie R. McMullen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure

Author(s) -

Ruby C.Y. Lin,

Kate L. Weeks,

XiaoMing Gao,

Rohan B. H. Williams,

Bianca C. Bernardo,

Helen Kiriazis,

Vance B. Matthews,

Elizabeth A. Woodcock,

Russell D. Bouwman,

Janelle P. Mollica,

H. J. L. Speirs,

Ian W. Dawes,

Roger J. Daly,

Tetsuo Shioi,

Seigo Izumo,

Mark A. Febbraio,

XiaoJun Du,

Julie R. McMullen

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.201988

Subject(s) - pi3k/akt/mtor pathway , heart failure , myocardial infarction , medicine , cardiac function curve , cardiology , endocrinology , biology , microbiology and biotechnology , signal transduction

Myocardial infarction (MI) is a serious complication of atherosclerosis associated with increasing mortality attributable to heart failure. Activation of phosphoinositide 3-kinase [PI3K(p110 alpha)] is considered a new strategy for the treatment of heart failure. However, whether PI3K(p110 alpha) provides protection in a setting of MI is unknown, and PI3K(p110 alpha) is difficult to target because it has multiple actions in numerous cell types. The goal of this study was to assess whether PI3K(p110 alpha) is beneficial in a setting of MI and, if so, to identify cardiac-selective microRNA and mRNA that mediate the protective properties of PI3K(p110 alpha).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research