Nutrient Modification of the Innate Immune Response | Zendy

Eric A. Schwartz | Zendy; Wei-Yang Zhang | Zendy; Sheetal K. Karnik | Zendy; Sabine Borwege | Zendy; Vijay R. Anand | Zendy; Phyllis S. Laine | Zendy; Yali Su | Zendy; Peter D. Reaven | Zendy

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Nutrient Modification of the Innate Immune Response

Author(s) -

Eric A. Schwartz,

Wei-Yang Zhang,

Sheetal K. Karnik,

Sabine Borwege,

Vijay R. Anand,

Phyllis S. Laine,

Yali Su,

Peter D. Reaven

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.201681

Subject(s) - inflammation , innate immune system , ceramide , monocyte , toll like receptor , lipopolysaccharide , mapk/erk pathway , biology , immune system , protein kinase c , microbiology and biotechnology , receptor , p38 mitogen activated protein kinases , signal transduction , macrophage , immunology , biochemistry , in vitro , apoptosis

Monocyte/macrophage inflammation is an important contributor to diabetes and cardiovascular disease. Studies have suggested saturated fatty acids (SFA) induce monocyte inflammation in a Toll-like receptor-4-dependent manner, but recent data suggest SFA do not directly interact with Toll-like receptor-4. The present study tests the novel hypothesis that metabolism of SFA cooperatively amplifies Toll-like receptor-4-mediated inflammation.

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