Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice | Zendy

Tanja K. Rudolph | Zendy; Volker Rudolph | Zendy; Martín M. Edreira | Zendy; Marsha P. Cole | Zendy; Gustavo Bonacci | Zendy; Francisco J. Schöpfer | Zendy; Steven R. Woodcock | Zendy; Andreas Franek | Zendy; Michaela Pekarová | Zendy; Nicholas K.H. Khoo | Zendy; Alyssa H. Hasty | Zendy; Stephan Baldus | Zendy; Bruce Α. Freeman | Zendy

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Nitro–Fatty Acids Reduce Atherosclerosis in Apolipoprotein E–Deficient Mice

Author(s) -

Tanja K. Rudolph,

Volker Rudolph,

Martín M. Edreira,

Marsha P. Cole,

Gustavo Bonacci,

Francisco J. Schöpfer,

Steven R. Woodcock,

Andreas Franek,

Michaela Pekarová,

Nicholas K.H. Khoo,

Alyssa H. Hasty,

Stephan Baldus,

Bruce Α. Freeman

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.201582

Subject(s) - chemistry , oleic acid , foam cell , nitric oxide , biochemistry , apolipoprotein b , lipoprotein , fatty acid , cholesterol , organic chemistry

Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide- and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.

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