Cell-Derived Microparticles in the Pathogenesis of Cardiovascular Disease | Zendy

Maarten E. Tushuizen | Zendy; Michaëla Diamant | Zendy; Augueste Sturk | Zendy; Rienk Nieuwland | Zendy

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Cell-Derived Microparticles in the Pathogenesis of Cardiovascular Disease

Author(s) -

Maarten E. Tushuizen,

Michaëla Diamant,

Augueste Sturk,

Rienk Nieuwland

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.200998

Subject(s) - disease , pathogenesis , inflammation , coagulation , homeostasis , function (biology) , medicine , microbiology and biotechnology , immunology , biology , pathology

Microparticles are ascribed important roles in coagulation, inflammation, and endothelial function. These processes are mandatory to safeguard the integrity of the organism, and their derangements contribute to the development of atherosclerosis and cardiovascular disease. More recently, the presumed solely harmful role of microparticles has been challenged because microparticles may also be involved in the maintenance and preservation of cellular homeostasis and in promoting defense mechanisms. Here, we summarize recent studies revealing these 2 faces of microparticles in cardiovascular disease.

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