Effects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice | Zendy

Dai Yamanouchi | Zendy; Stephanie Morgan | Zendy; Kaori Kato | Zendy; Justin Lengfeld | Zendy; Fan Zhang | Zendy; Bo Liu | Zendy

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Effects of Caspase Inhibitor on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice

Author(s) -

Dai Yamanouchi,

Stephanie Morgan,

Kaori Kato,

Justin Lengfeld,

Fan Zhang,

Bo Liu

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.200527

Subject(s) - angiotensin ii , apoptosis , inflammation , pathogenesis , abdominal aortic aneurysm , medicine , aortic aneurysm , endocrinology , chemistry , immunology , aorta , aneurysm , receptor , surgery , biochemistry

The presence of apoptotic markers is a prominent histological feature of abdominal aortic aneurysm. To understand the role of apoptosis in the pathogenesis of this common vascular disease, we tested the effect of the pan-caspase inhibitor quinoline-Val-Asp-difluorophenoxymethylketone (Q-VD-OPh) on aneurysm formation using a mouse angiotensin II (Ang II) model.

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