The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages | Zendy

Margarita de la Llera-Moya | Zendy; Denise DrazulSchrader | Zendy; Bela F. Asztalos | Zendy; Marina Cuchel | Zendy; Daniel J. Rader | Zendy; George H. Rothblat | Zendy

Open Access

The Ability to Promote Efflux Via ABCA1 Determines the Capacity of Serum Specimens With Similar High-Density Lipoprotein Cholesterol to Remove Cholesterol From Macrophages

Author(s) -

Margarita de la Llera-Moya,

Denise DrazulSchrader,

Bela F. Asztalos,

Marina Cuchel,

Daniel J. Rader,

George H. Rothblat

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.199158

Subject(s) - efflux , abca1 , cholesterol , abcg1 , apolipoprotein b , chemistry , high density lipoprotein , lipoprotein , endocrinology , biology , medicine , biochemistry , transporter , gene

We measured efflux from macrophages to apolipoprotein B-depleted serum from 263 specimens and found instances in which serum having similar high-density lipoprotein cholesterol (HDL-C) differed in their efflux capacity. Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I).

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