Magnetic Resonance Molecular Imaging of Thrombosis in an Arachidonic Acid Mouse Model Using an Activated Platelet Targeted Probe | Zendy

Ahmed Klink | Zendy; Eric Lancelot | Zendy; Sébastien Ballet | Zendy; Esad Vucic | Zendy; J Fabre | Zendy; Walter González | Zendy; Christelle Medina | Zendy; Claire Corot | Zendy; Willem J. M. Mulder | Zendy; Ziad Mallat | Zendy; Zahi A. Fayad | Zendy

Open Access

Magnetic Resonance Molecular Imaging of Thrombosis in an Arachidonic Acid Mouse Model Using an Activated Platelet Targeted Probe

Author(s) -

Ahmed Klink,

Eric Lancelot,

Sébastien Ballet,

Esad Vucic,

J Fabre,

Walter González,

Christelle Medina,

Claire Corot,

Willem J. M. Mulder,

Ziad Mallat,

Zahi A. Fayad

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.198556

Subject(s) - thrombus , in vivo , platelet , magnetic resonance imaging , medicine , platelet activation , thrombosis , pathology , mri contrast agent , stroke (engine) , arachidonic acid , radiology , chemistry , biology , biochemistry , mechanical engineering , microbiology and biotechnology , engineering , enzyme

Atherosclerotic plaque rupture leads to acute thrombus formation and may trigger serious clinical events such as myocardial infarction or stroke. Therefore, it would be valuable to identify atherothrombosis and vulnerable plaques before the onset of such clinical events. We sought to determine whether the noninvasive in vivo visualization of activated platelets was effective when using a target-specific MRI contrast agent to identify thrombi, hallmarks of vulnerable or high-risk atherosclerotic plaques.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research