Open AccessHuman Apolipoprotein A-II Determines Plasma Triglycerides by Regulating Lipoprotein Lipase Activity and High-Density Lipoprotein Proteome
Author(s) -
Josep Julve,
Joan Carles EscolàGil,
Noemí Rotllán,
Catherine Fiévet,
Emmanuelle Vallez,
Carolina de la Torre,
Vicent Ribas,
John H. Sloan,
Francisco BlancoVaca
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.198226
Subject(s) - lipoprotein lipase , apolipoprotein b , low density lipoprotein receptor related protein 8 , apolipoprotein c2 , lipoprotein , human plasma , plasma lipoprotein , high density lipoprotein , very low density lipoprotein , lipase , chemistry , apolipoprotein e , medicine , biochemistry , enzyme , cholesterol , chromatography , disease
Apolipoprotein (apo) A-II is the second most abundant high-density lipoprotein (HDL) apolipoprotein. We assessed the mechanism involved in the altered postprandial triglyceride-rich lipoprotein metabolism of female human apoA-II-transgenic mice (hapoA-II-Tg mice), which results in up to an 11-fold increase in plasma triglyceride concentration. The relationships between apoA-II, HDL composition, and lipoprotein lipase (LPL) activity were also analyzed in a group of normolipidemic women.
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