Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca 2+ Influx | Zendy

Xin Ma | Zendy; Shuang Qiu | Zendy; Jianhong Luo | Zendy; Yan Ma | Zendy; ChingYuen Ngai | Zendy; Bing Shen | Zendy; ChingOn Wong | Zendy; Yü Huang | Zendy; Xiaoqiang Yao | Zendy

Open Access

Functional Role of Vanilloid Transient Receptor Potential 4-Canonical Transient Receptor Potential 1 Complex in Flow-Induced Ca ²⁺ Influx

Author(s) -

Xin Ma,

Shuang Qiu,

Jianhong Luo,

Yan Ma,

ChingYuen Ngai,

Bing Shen,

ChingOn Wong,

Yü Huang,

Xiaoqiang Yao

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.196584

Subject(s) - transient receptor potential channel , transient (computer programming) , receptor potential , receptor , chemistry , biophysics , trpv1 , biology , biochemistry , computer science , operating system

The present study is aimed at investigating the interaction of TRPV4 with TRPC1 and the functional role of such an interaction in flow-induced Ca(2+) influx. Hemodynamic blood flow is an important physiological factor that modulates vascular tone. One critical early event in this process is a cytosolic Ca(2+) ([Ca(2+)](i)) rise in endothelial cells in response to flow.

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