Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway | Zendy

Thomas M. van Himbergen | Zendy; Seiko Otokozawa | Zendy; Nirupa R. Matthan | Zendy; Ernst J. Schaefer | Zendy; Aaron Buchsbaum | Zendy; Masumi Ai | Zendy; Lambertus J.H. van Tits | Zendy; Jacqueline de Graaf | Zendy; Anton F. H. Stalenhoef | Zendy

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Familial Combined Hyperlipidemia Is Associated With Alterations in the Cholesterol Synthesis Pathway

Author(s) -

Thomas M. van Himbergen,

Seiko Otokozawa,

Nirupa R. Matthan,

Ernst J. Schaefer,

Aaron Buchsbaum,

Masumi Ai,

Lambertus J.H. van Tits,

Jacqueline de Graaf,

Anton F. H. Stalenhoef

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.196550

Subject(s) - lathosterol , desmosterol , squalene , cholestanol , cholesterol , medicine , campesterol , endocrinology , hyperlipidemia , sterol , chemistry , apolipoprotein b , biochemistry , diabetes mellitus

Familial combined hyperlipidemia (FCH) is a common familial lipid disorder characterized by increases in plasma total cholesterol, triglyceride, and apolipoprotein B-100 levels. In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members.

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