Human Sickle Cell Blood Modulates Endothelial Heme Oxygenase Activity | Zendy

Sandip K. Bains | Zendy; Roberta Foresti | Zendy; Jo Howard | Zendy; Sangeeta Atwal | Zendy; Colin J. Green | Zendy; Roberto Motterlini | Zendy

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Human Sickle Cell Blood Modulates Endothelial Heme Oxygenase Activity

Author(s) -

Sandip K. Bains,

Roberta Foresti,

Jo Howard,

Sangeeta Atwal,

Colin J. Green,

Roberto Motterlini

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.196360

Subject(s) - heme , heme oxygenase , biliverdin , hemoglobin , bilirubin , hemolysis , sickle cell anemia , endothelium , red blood cell , hypoxia (environmental) , medicine , biochemistry , endocrinology , chemistry , immunology , cell , enzyme , oxygen , organic chemistry

Sickle cell disease (SCD) is characterized by extensive hemolysis, increased cellular adhesion, and vaso-occlusion. Tissues from sickle patients express heme oxygenase-1 (HO-1), the enzyme that degrades free heme/hemoglobin to the signaling molecule carbon monoxide, and the antioxidants biliverdin/bilirubin. Here, we examined the HO response in endothelial cells exposed to human sickle blood and determined whether this response is beneficial for SCD.

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