Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression | Zendy

Kotaro Takeda | Zendy; Toshihiro Ichiki | Zendy; Eriko Narabayashi | Zendy; Keita Inanaga | Zendy; Ryohei Miyazaki | Zendy; Toru Hashimoto | Zendy; Hirohide Matsuura | Zendy; Jiro Ikeda | Zendy; Toshio Miyata | Zendy; Kenji Sunagawa | Zendy

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Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

Author(s) -

Kotaro Takeda,

Toshihiro Ichiki,

Eriko Narabayashi,

Keita Inanaga,

Ryohei Miyazaki,

Toru Hashimoto,

Hirohide Matsuura,

Jiro Ikeda,

Toshio Miyata,

Kenji Sunagawa

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.196071

Subject(s) - downregulation and upregulation , tumor necrosis factor alpha , lipopolysaccharide , hypoxia inducible factors , transcription factor , inflammation , microbiology and biotechnology , rna interference , chemistry , biology , immunology , rna , biochemistry , gene

Prolyl hydroxylase domain-containing proteins (PHDs) play pivotal roles in oxygen-sensing system through the regulation of alpha-subunit of hypoxia-inducible factor (HIF), a key transcription factor governing a large set of gene expression to adapt hypoxia. Although tissue hypoxia plays an essential role in maintaining inflammation, the role of PHDs in the inflammatory responses has not been clearly determined. Here, we investigated the role of PHDs in lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-alpha) induction in macrophages.

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