Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo | Zendy

Tomoyuki Yasuda | Zendy; Didier Grillot | Zendy; Jeffery T. Billheimer | Zendy; François Briand | Zendy; Philippe Delerive | Zendy; Stéphane Huet | Zendy; Daniel J. Rader | Zendy

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Tissue-Specific Liver X Receptor Activation Promotes Macrophage Reverse Cholesterol Transport In Vivo

Author(s) -

Tomoyuki Yasuda,

Didier Grillot,

Jeffery T. Billheimer,

François Briand,

Philippe Delerive,

Stéphane Huet,

Daniel J. Rader

Publication year - 2010

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.195693

Subject(s) - liver x receptor , agonist , in vivo , macrophage , reverse cholesterol transport , medicine , endocrinology , cholesterol , chemistry , biology , receptor , pharmacology , nuclear receptor , in vitro , biochemistry , lipoprotein , microbiology and biotechnology , transcription factor , gene

We previously reported that a systemic liver X receptor (LXR) agonist promoted macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in multiple tissues involved in RCT (macrophages, liver, intestine), we analyzed the effect of tissue-specific LXR agonism on mRCT.

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