Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis | Zendy

Yasushi Numaguchi | Zendy; Masakazu Ishii | Zendy; Ryuji Kubota | Zendy; Yasuhiro Morita | Zendy; Koji Yamamoto | Zendy; Tadashi Matsushita | Zendy; Kenji Okumura | Zendy; Toyoaki Murohara | Zendy

Open Access

Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis

Author(s) -

Yasushi Numaguchi,

Masakazu Ishii,

Ryuji Kubota,

Yasuhiro Morita,

Koji Yamamoto,

Tadashi Matsushita,

Kenji Okumura,

Toyoaki Murohara

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.195057

Subject(s) - fibrinolysis , medicine , thrombosis , plasminogen activator inhibitor 1 , plasminogen activator , endocrinology , angiotensin ii , platelet activation , platelet , receptor

Reduced fibrinolytic activity is associated with adverse cardiovascular events. Although insulin-regulated aminopeptidase (IRAP) was recently identified as the angiotensin (Ang) IV receptor (AT4R), the impact of AngIV-AT4R signaling distal to AngII on the activation of type-1 plasminogen activator inhibitor (PAI-1) in the fibrinolytic process and subsequent formation of thrombosis remains unclarified.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research