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Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events
Author(s) -
Dominique P.V. de Kleijn,
Frans L. Moll,
Willem E. Hellings,
Gonen OzsarlakSozer,
Peter de Bruin,
Pieter A. Doevendans,
Aryan Vink,
Louise M. Catanzariti,
Arjan H. Schoneveld,
Ale Algra,
Mat J.A.P. Daemen,
Erik A.L. Biessen,
Wilco de Jager,
Huoming Zhang,
Jean-Paul de Vries,
Erling Falk,
Sai Kiang Lim,
Peter J. van der Spek,
Siu Kwan Sze,
Gerard Pasterkamp
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.194944
Subject(s) - medicine , hazard ratio , quartile , confidence interval , osteopontin , cohort , biomarker , carotid endarterectomy , myocardial infarction , cardiology , proportional hazards model , stroke (engine) , stenosis , mechanical engineering , biochemistry , chemistry , engineering
Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.

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