Adenosine Modulates HIF-1α, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells | Zendy

Stefania Gessi | Zendy; Eleonora Fogli | Zendy; Valeria Sacchetto | Zendy; Stefania Merighi | Zendy; Katia Varani | Zendy; Delia Preti | Zendy; Edward Leung | Zendy; Stephen MacLennan | Zendy; Pier Andrea Borea | Zendy

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Adenosine Modulates HIF-1α, VEGF, IL-8, and Foam Cell Formation in a Human Model of Hypoxic Foam Cells

Author(s) -

Stefania Gessi,

Eleonora Fogli,

Valeria Sacchetto,

Stefania Merighi,

Katia Varani,

Delia Preti,

Edward Leung,

Stephen MacLennan,

Pier Andrea Borea

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.194902

Subject(s) - angiogenesis , protein kinase b , adenosine , mapk/erk pathway , microbiology and biotechnology , kinase , chemistry , p38 mitogen activated protein kinases , protein kinase a , phosphorylation , adenosine receptor , vascular endothelial growth factor , receptor , cancer research , biology , biochemistry , agonist , vegf receptors

Foam cell (FC) formation by oxidized low-density lipoprotein (oxLDL) accumulation in macrophages is crucial for development of atherosclerosis. Hypoxia has been demonstrated in atherosclerosis and hypoxia-inducible factor-1 (HIF-1) has been shown to promote intraplaque angiogenesis and FC development. As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs.

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