The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries | Zendy

Darcy Lidington | Zendy; Bernhard Friedrich Peter | Zendy; Anja Meißner | Zendy; Jeffrey T. Kroetsch | Zendy; Stuart M. Pitson | Zendy; Ulrich Pohl | Zendy; Steffen-Sebastian Bolz | Zendy

Open Access

The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries

Author(s) -

Darcy Lidington,

Bernhard Friedrich Peter,

Anja Meißner,

Jeffrey T. Kroetsch,

Stuart M. Pitson,

Ulrich Pohl,

Steffen-Sebastian Bolz

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.194803

Subject(s) - sphingosine kinase 1 , phosphorylation , sphingosine , microbiology and biotechnology , serine , extracellular , biology , intracellular , sphingosine 1 phosphate , chemistry , receptor , biochemistry

The purpose of this study was to characterize a phosphorylation motif at serine 225 as a molecular switch that regulates the pressure-dependent activation of sphingosine kinase 1 (Sk1) in resistance artery smooth muscle cells.

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