Matrix Metalloproteinase-10 Is Upregulated by Thrombin in Endothelial Cells and Increased in Patients With Enhanced Thrombin Generation | Zendy

Josune Orbe | Zendy; José Antonio Rodríguez | Zendy; Olivier Calvayrac | Zendy; Ricardo RodríguezCalvo | Zendy; Cristina Rodrı́guez | Zendy; Carmen Roncal | Zendy; Sara Martínez de Lizarrondo | Zendy; Jaione Barrenetxe | Zendy; Joan Carles Reverter | Zendy; José MartínezGonzález | Zendy; José A. Páramo | Zendy

Open Access

Matrix Metalloproteinase-10 Is Upregulated by Thrombin in Endothelial Cells and Increased in Patients With Enhanced Thrombin Generation

Author(s) -

Josune Orbe,

José Antonio Rodríguez,

Olivier Calvayrac,

Ricardo RodríguezCalvo,

Cristina Rodrı́guez,

Carmen Roncal,

Sara Martínez de Lizarrondo,

Jaione Barrenetxe,

Joan Carles Reverter,

José MartínezGonzález,

José A. Páramo

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.194589

Subject(s) - thrombin , thrombomodulin , proinflammatory cytokine , downregulation and upregulation , thrombin receptor , chemistry , microbiology and biotechnology , matrix metalloproteinase , endothelial stem cell , protease activated receptor , biology , immunology , inflammation , biochemistry , platelet , in vitro , gene

Thrombin is a multifunctional serine protease that promotes vascular proinflammatory responses whose effect on endothelial MMP-10 expression has not previously been evaluated.

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