Open AccessSmooth Muscle LDL Receptor-Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation
Author(s) -
Joshua E. Basford,
Zachary W.Q. Moore,
Li Zhou,
Joachim Herz,
David Y. Hui
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.194357
Subject(s) - neointima , calponin , lrp1 , vascular smooth muscle , medicine , endocrinology , neointimal hyperplasia , microbiology and biotechnology , biology , ldl receptor , chemistry , lipoprotein , smooth muscle , restenosis , cholesterol , stent
Defective smooth muscle expression of LDL receptor-related protein-1 (Lrp1) increases atherosclerosis in hypercholesterolemic mice. This study explored the importance of smooth muscle Lrp1 expression under normolipidemic conditions.
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