Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling | Zendy

Clett Erridge | Zendy; Nilesh J. Samani | Zendy

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Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

Author(s) -

Clett Erridge,

Nilesh J. Samani

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.194050

Subject(s) - tlr2 , tlr4 , receptor , toll like receptor , inflammation , microbiology and biotechnology , hek 293 cells , signal transduction , fatty acid , lipopeptide , biology , chemistry , biochemistry , innate immune system , immunology , bacteria , genetics

Toll-like receptors (TLRs) initiate inflammatory signaling in response to conserved microbial molecules. It has been proposed that dietary saturated fatty acids (SFAs) may also serve as endogenous ligands of TLR2 or TLR4, thereby promoting diseases associated with inflammation and dyslipidemia, including atherosclerosis and insulin resistance.

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