Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State | Zendy

Mustafa Zakkar | Zendy; Kim Van der Heiden | Zendy; Le Anh Luong | Zendy; Hera Chaudhury | Zendy; Chantal Simon | Zendy; Shahir Hamdulay | Zendy; Rob Krams | Zendy; Indika Edirisinghe | Zendy; Irfan Rahman | Zendy; Harald Carlsen | Zendy; Dorian O. Haskard | Zendy; Justin C. Mason | Zendy; Paul C. Evans | Zendy

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Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

Author(s) -

Mustafa Zakkar,

Kim Van der Heiden,

Le Anh Luong,

Hera Chaudhury,

Chantal Simon,

Shahir Hamdulay,

Rob Krams,

Indika Edirisinghe,

Irfan Rahman,

Harald Carlsen,

Dorian O. Haskard,

Justin C. Mason,

Paul C. Evans

Publication year - 2009

Publication title -

arteriosclerosis, thrombosis, and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.193375

Subject(s) - proinflammatory cytokine , p38 mitogen activated protein kinases , microbiology and biotechnology , activator (genetics) , chemistry , endothelial activation , signal transduction , inflammation , transcription factor , regulator , biology , immunology , mapk/erk pathway , biochemistry , receptor , gene

Proinflammatory mediators influence atherosclerosis by inducing adhesion molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries including p38 MAP kinase. Regions of arteries exposed to high shear stress are protected from inflammation and atherosclerosis, whereas low-shear regions are susceptible. Here we investigated whether the transcription factor Nrf2 regulates EC activation in arteries.

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