Lack of Tyrosylprotein Sulfotransferase Activity in Hematopoietic Cells Drastically Attenuates Atherosclerosis in Ldlr −/− Mice | Zendy

Andrew D. Westmuckett | Zendy; Kevin L. Moore | Zendy

Open Access

Lack of Tyrosylprotein Sulfotransferase Activity in Hematopoietic Cells Drastically Attenuates Atherosclerosis in Ldlr ^−/− Mice

Author(s) -

Andrew D. Westmuckett,

Kevin L. Moore

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.192963

Subject(s) - haematopoiesis , ldl receptor , chemistry , sulfotransferase , biochemistry , medicine , microbiology and biotechnology , endocrinology , biology , cholesterol , lipoprotein , enzyme , stem cell

Leukocyte recruitment is a major contributor in the development of atherosclerosis and requires a variety of proteins such as adhesion molecules, chemokines, and chemokine receptors. Several key molecular players implicated in this process are expressed on monocytes and require protein-tyrosine sulfation for optimal function in vitro, including human CCR2, CCR5, CX3CR1, and PSGL-1. We therefore hypothesized that protein-tyrosine sulfation in hematopoietic cells plays an important role in the development of atherosclerosis.

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