Open AccessInactivation of the LRP1 Intracellular NPxYxxL Motif in LDLR-Deficient Mice Enhances Postprandial Dyslipidemia and Atherosclerosis
Author(s) -
Philip L.S.M. Gordts,
Sara Reekmans,
Annick Lauwers,
Amber Van Dongen,
Leen Verbeek,
Anton Roebroek
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.192211
Subject(s) - postprandial , ldl receptor , dyslipidemia , lrp1 , intracellular , pcsk9 , medicine , endocrinology , chemistry , lipoprotein , cholesterol , biochemistry , diabetes mellitus
The purpose of this study was to determine the significance of the intracellular NPxYxxL motif of LRP1 for the atheroprotective role of this multifunctional receptor.
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