Open AccessPYK2/PDZ-RhoGEF Links Ca 2+ Signaling to RhoA
Author(s) -
Zhekang Ying,
Fernanda R. Giachini,
Rita C. Tostes,
R. Clinton Webb
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.109.190892
Subject(s) - rhoa , pdz domain , guanine nucleotide exchange factor , microbiology and biotechnology , biology , phosphorylation , angiotensin ii , rho associated protein kinase , tyrosine phosphorylation , signal transduction , biochemistry , receptor
Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca(2+) sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA.
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