Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1 | Zendy

Katsutaka Oishi | Zendy; Daisuke Uchida | Zendy; Naoki Ohkura | Zendy; Ryosuke Doi | Zendy; Norio Ishida | Zendy; Koji Kadota | Zendy; Shuichi Horie | Zendy

Open Access

Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1

Author(s) -

Katsutaka Oishi,

Daisuke Uchida,

Naoki Ohkura,

Ryosuke Doi,

Norio Ishida,

Koji Kadota,

Shuichi Horie

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.190140

Subject(s) - circadian rhythm , activator (genetics) , circadian clock , endocrinology , medicine , plasminogen activator , ketogenic diet , chemistry , biology , neuroscience , epilepsy , receptor

Metabolic disorders such as diabetes and obesity are considered risk factors for cardiovascular diseases by increasing levels of blood plasminogen activator inhibitor-1 (PAI-1). Ketogenic diets (KDs) have been used as an approach to weight loss in both obese and nonobese individuals. We examined circadian changes in plasma PAI-1 and its mRNA expression levels in tissues from mice fed with a KD (KD mice), to evaluate its effects on fibrinolytic functions.

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