Syndecan-1 | Zendy

Nozomi Fukai | Zendy; Richard D. Kenagy | Zendy; Lihua Chen | Zendy; Lu Gao | Zendy; Guenter Daum | Zendy; Alexander W. Clowes | Zendy

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Syndecan-1

Author(s) -

Nozomi Fukai,

Richard D. Kenagy,

Lihua Chen,

Lu Gao,

Guenter Daum,

Alexander W. Clowes

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.190132

Subject(s) - syndecan 1 , biology , medicine , genetics , cell

Arterial injury induces smooth muscle cell (SMC) proliferation, migration, and intimal accumulation of cells and extracellular matrix. These processes are regulated by the administration of the glycosaminoglycans heparin and heparan sulfate, but little is known about the role of endogenous heparan sulfate proteoglycans in the vessel wall. We investigated the response to carotid injury of syndecan-1-null mice to assess the function of one of a conserved family of transmembrane heparan and chondroitin sulfate proteoglycans.

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