ENPP1 Q121 Variant, Increased Pulse Pressure and Reduced Insulin Signaling, and Nitric Oxide Synthase Activity in Endothelial Cells | Zendy

Simonetta Bacci | Zendy; Rosa Di Paola | Zendy; Claudia Menzaghi | Zendy; Patrizia Di Fulvio | Zendy; Sara Di Silvestre | Zendy; Fabio Pellegrini | Zendy; Roberto Baratta | Zendy; Antonella Marucci | Zendy; Sandra Mastroianno | Zendy; G. Fini | Zendy; Gloria Formoso | Zendy; Agostino Consoli | Zendy; Francesco Perticone | Zendy; Lucia Frittitta | Zendy; Assunta Pandolfi | Zendy; Vincenzo Trischitta | Zendy

Open Access

ENPP1 Q121 Variant, Increased Pulse Pressure and Reduced Insulin Signaling, and Nitric Oxide Synthase Activity in Endothelial Cells

Author(s) -

Simonetta Bacci,

Rosa Di Paola,

Claudia Menzaghi,

Patrizia Di Fulvio,

Sara Di Silvestre,

Fabio Pellegrini,

Roberto Baratta,

Antonella Marucci,

Sandra Mastroianno,

G. Fini,

Gloria Formoso,

Agostino Consoli,

Francesco Perticone,

Lucia Frittitta,

Assunta Pandolfi,

Vincenzo Trischitta

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.189191

Subject(s) - insulin resistance , endocrinology , medicine , insulin , autophosphorylation , insulin receptor , nitric oxide , protein kinase b , endothelial dysfunction , heritability , nitric oxide synthase , biology , phosphorylation , biochemistry , genetics , protein kinase a

Insulin resistance induces increased pulse pressure (PP), endothelial dysfunction (ED), and reduced bioavailability of endothelium-derived nitric oxide (NO). The genetic background of these 3 cardiovascular risk factors might be partly common. The ENPP1 K121Q polymorphism is associated with insulin resistance and cardiovascular risk.

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