Genetic Association and Interaction Analysis of USF1 and APOA5 on Lipid Levels and Atherosclerosis | Zendy

PirkkaPekka Laurila | Zendy; Jussi Naukkarinen | Zendy; Kati Kristiansson | Zendy; Samuli Ripatti | Zendy; Tuuli Kauttu | Zendy; Kaisa Silander | Zendy; Veikko Salomaa | Zendy; Markus Perola | Zendy; Pekka J. Karhunen | Zendy; Philip J. Barter | Zendy; Christian Ehnholm | Zendy; Leena Peltonen | Zendy

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Genetic Association and Interaction Analysis of USF1 and APOA5 on Lipid Levels and Atherosclerosis

Author(s) -

PirkkaPekka Laurila,

Jussi Naukkarinen,

Kati Kristiansson,

Samuli Ripatti,

Tuuli Kauttu,

Kaisa Silander,

Veikko Salomaa,

Markus Perola,

Pekka J. Karhunen,

Philip J. Barter,

Christian Ehnholm,

Leena Peltonen

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.188912

Subject(s) - dyslipidemia , coronary artery disease , medicine , autopsy , lesion , population , coronary atherosclerosis , disease , bioinformatics , pathology , cardiology , biology , environmental health

USF1 is a ubiquitous transcription factor governing the expression of numerous genes of lipid and glucose metabolism. APOA5 is a well-established candidate gene regulating triglyceride (TG) levels and has been identified as a downstream target of upstream stimulatory factor. No detailed studies about the effect of APOA5 on atherosclerotic lesion formation have been conducted, nor has its potential interaction with USF1 been examined.

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