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Impaired hepatic phosphatidylcholine (PC) synthesis lowers plasma lipids. We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis.

Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice