Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice | Zendy

Yang Zhao | Zendy; Brian Su | Zendy; René L. Jacobs | Zendy; Brian P. Kennedy | Zendy; Gordon A. Francis | Zendy; Emma Waddington | Zendy; John T. Brosnan | Zendy; Jean E. Vance | Zendy; Dennis E. Vance | Zendy

Open Access

Lack of Phosphatidylethanolamine N -Methyltransferase Alters Plasma VLDL Phospholipids and Attenuates Atherosclerosis in Mice

Author(s) -

Yang Zhao,

Brian Su,

René L. Jacobs,

Brian P. Kennedy,

Gordon A. Francis,

Emma Waddington,

John T. Brosnan,

Jean E. Vance,

Dennis E. Vance

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.188672

Subject(s) - medicine , endocrinology , ldl receptor , very low density lipoprotein , lipoprotein , apolipoprotein b , phosphatidylethanolamine , intermediate density lipoprotein , chemistry , cholesterol , low density lipoprotein , apolipoprotein e , phospholipid , biology , phosphatidylcholine , biochemistry , disease , membrane

Impaired hepatic phosphatidylcholine (PC) synthesis lowers plasma lipids. We, therefore, tested the hypothesis that lack of phosphatidylethanolamine N-methyltransferase (PEMT), a hepatic enzyme catalyzing PC biosynthesis, attenuates the development of atherosclerosis.

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