Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation | Zendy

Sarah T.B.G. Loubele | Zendy; C. Arnold Spek | Zendy; Peter Leenders | Zendy; René van Oerle | Zendy; Hella L. Aberson | Zendy; Karly Hamulyák | Zendy; Gary Ferrell | Zendy; Charles T. Esmon | Zendy; Henri M.H. Spronk | Zendy; Hugo Ten Cate | Zendy

Open Access

Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation

Author(s) -

Sarah T.B.G. Loubele,

C. Arnold Spek,

Peter Leenders,

René van Oerle,

Hella L. Aberson,

Karly Hamulyák,

Gary Ferrell,

Charles T. Esmon,

Henri M.H. Spronk,

Hugo Ten Cate

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.188656

Subject(s) - inflammation , medicine , reperfusion injury , protein c , apoptosis , ischemia , pharmacology , myocardial infarction , mediator , immunology , biology , biochemistry

In spite of major advances in reperfusion therapy for patients presenting with acute coronary syndrome, long-term morbidity is still substantial. A limitation of initial treatment of myocardial ischemia is the lack of prevention of ischemia/reperfusion (I/R) injury. Activated protein C (APC), a crucial mediator in the coagulation process, plays a prominent role in the crosstalk between coagulation and inflammation and provides cytoprotective effects via inhibition of apoptosis and inflammation in several human and animal studies.

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