Control of ACAT2 Liver Expression by HNF4α | Zendy

Camilla Pramfalk | Zendy; Eva Nordberg Karlsson | Zendy; Leif Groop | Zendy; L L Rudel | Zendy; Bo Angelin | Zendy; Mats Eriksson | Zendy; Paolo Parini | Zendy

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Control of ACAT2 Liver Expression by HNF4α

Author(s) -

Camilla Pramfalk,

Eva Nordberg Karlsson,

Leif Groop,

L L Rudel,

Bo Angelin,

Mats Eriksson,

Paolo Parini

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.188581

Subject(s) - very low density lipoprotein , regulator , lipoprotein , cholesterylester transfer protein , cholesterol , chemistry , biology , gene , medicine , endocrinology , biochemistry

ACAT2 is thought to be responsible for cholesteryl ester production in chylomicron and VLDL assembly. Recently, we identified HNF1alpha as an important regulator of the human ACAT2 promoter. Thus, we hypothesized that MODY3 (HNF1alpha gene mutations) and possibly MODY1 (HNF4alpha, upstream regulator of HNF1alpha, gene mutations) subjects may have lower VLDL esterified cholesterol.

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