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Inducible expression of cyclooxygenase-2 (COX-2) and terminal prostaglandin synthases (tPGS) has been mainly analyzed in tumor, stromal, and inflammatory cells, and little is known about the regulation of prostanoid biosynthesis by endothelial cells. Here we characterize the profile of prostanoids produced by activated HUVECs and analyze the expression and activities of tPGS.

COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2for Transcellular Metabolism to PGE2by Tumor Cells

COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH₂for Transcellular Metabolism to PGE₂by Tumor Cells