Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice | Zendy

Huan Wang | Zendy; Weiyu Zhang | Zendy; Rong Tang | Zendy; Robert P. Hebbel | Zendy; M. Anna Kowalska | Zendy; Chunxiang Zhang | Zendy; Jamey D. Marth | Zendy; Minoru Fukuda | Zendy; Chuhong Zhu | Zendy; Yuqing Huo | Zendy

Open Access

Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice

Author(s) -

Huan Wang,

Weiyu Zhang,

Rong Tang,

Robert P. Hebbel,

M. Anna Kowalska,

Chunxiang Zhang,

Jamey D. Marth,

Minoru Fukuda,

Chuhong Zhu,

Yuqing Huo

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.187716

Subject(s) - neointima , apolipoprotein e , restenosis , medicine , platelet , regeneration (biology) , endothelial dysfunction , pathology , endocrinology , microbiology and biotechnology , biology , stent , disease

Core2 1 to 6-N-glucosaminyltransferase-I (C2GlcNAcT-I) plays an important role in optimizing the binding functions of several selectin ligands, including P-selectin glycoprotein ligand. We used apolipoprotein E (ApoE)-deficient atherosclerotic mice to investigate the role of C2GlcNAcT-I in platelet and leukocyte interactions with injured arterial walls, in endothelial regeneration at injured sites, and in the formation of arterial neointima.

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