Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides | Zendy

Takeshi Tokudome | Zendy; Ichiro Kishimoto | Zendy; Kenichi Yamahara | Zendy; Tsukasa Osaki | Zendy; Naoto Minamino | Zendy; Takeshi Horio | Zendy; Kazutomo Sawai | Zendy; Yuhei Kawano | Zendy; Mikiya Miyazato | Zendy; Masataka Sata | Zendy; Masakazu Kohno | Zendy; Kazuwa Nakao | Zendy; Kenji Kangawa | Zendy

Open Access

Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides

Author(s) -

Takeshi Tokudome,

Ichiro Kishimoto,

Kenichi Yamahara,

Tsukasa Osaki,

Naoto Minamino,

Takeshi Horio,

Kazutomo Sawai,

Yuhei Kawano,

Mikiya Miyazato,

Masataka Sata,

Masakazu Kohno,

Kazuwa Nakao,

Kenji Kangawa

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.187526

Subject(s) - guanylate cyclase , medicine , hindlimb , cardiology , ischemia , blood flow , endocrinology , receptor

Atrial and brain natriuretic peptides (ANP and BNP, respectively) function via guanylyl cyclase (GC)-A, resulting in diuresis, natriuresis, and blood vessel dilation. Here, we investigated the role of endogenous ANP/BNP-GC-A signaling on reparative vascular remodeling using a hind-limb ischemia model.

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