Monocytes and Neutrophils Exhibit Both Distinct and Common Mechanisms in Penetrating the Vascular Basement Membrane In Vivo | Zendy

Mathieu-Benoı̂t Voisin | Zendy; Abigail Woodfin | Zendy; Sussan Nourshargh | Zendy

Open Access

Monocytes and Neutrophils Exhibit Both Distinct and Common Mechanisms in Penetrating the Vascular Basement Membrane In Vivo

Author(s) -

Mathieu-Benoı̂t Voisin,

Abigail Woodfin,

Sussan Nourshargh

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.187450

Subject(s) - in vivo , basement membrane , monocyte , inflammation , microbiology and biotechnology , biology , immunology , chemotaxis , in vitro , chemistry , receptor , biochemistry , genetics

Leukocyte migration through venular walls is a fundamental event during inflammation, but many aspects of this response, including the mechanisms associated with leukocyte migration through the vascular basement membrane (BM) in vivo, are poorly understood. Here we investigated and compared the means by which neutrophils and monocytes migrate through the venular BM. Specifically, as we have previously reported on the existence of neutrophil permissive sites (termed matrix protein low expression regions; LERs) within the venular BM, we have now investigated the role of these sites in monocyte transmigration in vivo.

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