Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice | Zendy

Carla Iacobini | Zendy; Stefano Menini | Zendy; Pier Carlo Ricci | Zendy; Angela Scipioni | Zendy; Viola Sansoni | Zendy; Samantha Cordone | Zendy; Maurizio Taurino | Zendy; Matteo Sérino | Zendy; Giuseppe Marano | Zendy; Massimo Federici | Zendy; Flavia Pricci | Zendy; Giuseppe Pugliese | Zendy

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Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice

Author(s) -

Carla Iacobini,

Stefano Menini,

Pier Carlo Ricci,

Angela Scipioni,

Viola Sansoni,

Samantha Cordone,

Maurizio Taurino,

Matteo Sérino,

Giuseppe Marano,

Massimo Federici,

Flavia Pricci,

Giuseppe Pugliese

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.186791

Subject(s) - proinflammatory cytokine , downregulation and upregulation , inflammation , receptor , galectin 3 , foam cell , monocyte , biology , endocrinology , medicine , chemistry , immunology , lipoprotein , cholesterol , biochemistry , gene

Modified lipoproteins, particularly oxidized LDLs, are believed to evoke an inflammatory response which participates in all stages of atherosclerosis. Disposal of these particles is mediated through receptors which may trigger proinflammatory signaling pathways leading to vascular injury. This study was aimed at assessing the role in atherogenesis of one of these receptors, galectin-3.

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