Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells | Zendy

Helen M. Jopling | Zendy; Adam F. Odell | Zendy; Nigel M. Hooper | Zendy; Ian Zachary | Zendy; John H. Walker | Zendy; Sreenivasan Ponnambalam | Zendy

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Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells

Author(s) -

Helen M. Jopling,

Adam F. Odell,

Nigel M. Hooper,

Ian Zachary,

John H. Walker,

Sreenivasan Ponnambalam

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.186239

Subject(s) - rab , microbiology and biotechnology , endosome , gtpase , biology , small gtpase , endocytic cycle , phosphorylation , kinase insert domain receptor , signal transduction , endocytosis , vascular endothelial growth factor a , receptor , vascular endothelial growth factor , cancer research , biochemistry , intracellular , vegf receptors

Vascular endothelial growth factor receptor 2 (VEGFR2) is a receptor tyrosine kinase that regulates vascular physiology. However, mechanism(s) by which VEGFR2 signaling and trafficking is coordinated are not clear. Here, we have tested endocytic Rab GTPases for regulation of VEGFR2 trafficking and signaling linked to endothelial cell migration.

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