Thrombin Induces EGF Receptor Expression and Cell Proliferation via a PKC(δ)/c-Src-Dependent Pathway in Vascular Smooth Muscle Cells | Zendy

HsiLung Hsieh | Zendy; WeiHsuan Tung | Zendy; ChengYing Wu | Zendy; Hui-Hsin Wang | Zendy; ChihChung Lin | Zendy; Tze-Shyuan Wang | Zendy; ChuenMao Yang | Zendy

Open Access

Thrombin Induces EGF Receptor Expression and Cell Proliferation via a PKC(δ)/c-Src-Dependent Pathway in Vascular Smooth Muscle Cells

Author(s) -

HsiLung Hsieh,

WeiHsuan Tung,

ChengYing Wu,

Hui-Hsin Wang,

ChihChung Lin,

Tze-Shyuan Wang,

ChuenMao Yang

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.185801

Subject(s) - transactivation , small hairpin rna , vascular smooth muscle , downregulation and upregulation , thrombin , protein kinase b , pi3k/akt/mtor pathway , small interfering rna , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , mapk/erk pathway , thrombin receptor , chemistry , signal transduction , cancer research , biology , transcription factor , cell culture , gene knockdown , endocrinology , transfection , immunology , biochemistry , genetics , platelet , smooth muscle , gene

Thrombin upregulates expression of several proteins in vascular smooth muscle cells (VSMCs) which may contribute to atherosclerosis. Here, we investigated the mechanisms underlying thrombin-induced EGF receptor (EGFR) expression and its effect on VSMCs.

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