Protective Role of SIRT1 in Diabetic Vascular Dysfunction | Zendy

Masayuki Orimo | Zendy; Tohru Minamino | Zendy; Hideyuki Miyauchi | Zendy; Kaoru Tateno | Zendy; Sho Okada | Zendy; Junji Moriya | Zendy; Issei Komuro | Zendy

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Protective Role of SIRT1 in Diabetic Vascular Dysfunction

Author(s) -

Masayuki Orimo,

Tohru Minamino,

Hideyuki Miyauchi,

Kaoru Tateno,

Sho Okada,

Junji Moriya,

Issei Komuro

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.185694

Subject(s) - sirtuin 1 , senescence , downregulation and upregulation , endothelial dysfunction , calorie restriction , biology , sirt6 , acetylation , nad+ kinase , pathogenesis , gene silencing , diabetes mellitus , regulator , hdac3 , microbiology and biotechnology , endothelial stem cell , endocrinology , oxidative stress , medicine , histone deacetylase , sirtuin , immunology , biochemistry , histone , gene , in vitro , enzyme

Calorie restriction (CR) prolongs the lifespan of various species, ranging from yeasts to mice. In yeast, CR extends the lifespan by increasing the activity of silencing information regulator 2 (Sir2), an NAD(+)-dependent deacetylase. SIRT1, a mammalian homolog of Sir2, has been reported to downregulate p53 activity and thereby prolong the lifespan of cells. Although recent evidence suggests a link between SIRT1 activity and metabolic homeostasis during CR, its pathological role in human disease is not yet fully understood.

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