Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage | Zendy

Judith Haendeler | Zendy; Stefan Dröse | Zendy; Nicole Büchner | Zendy; Sascha Jakob | Zendy; Joachim Altschmied | Zendy; Christine Goy | Zendy; Ioakim Spyridopoulos | Zendy; Andreas M. Zeiher | Zendy; Ulrich Brandt | Zendy; Stefanie Dimmeler | Zendy

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Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

Author(s) -

Judith Haendeler,

Stefan Dröse,

Nicole Büchner,

Sascha Jakob,

Joachim Altschmied,

Christine Goy,

Ioakim Spyridopoulos,

Andreas M. Zeiher,

Ulrich Brandt,

Stefanie Dimmeler

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.109.185546

Subject(s) - mitochondrial dna , mitochondrion , telomerase , biology , ethidium bromide , microbiology and biotechnology , dna damage , mitochondrial matrix , reverse transcriptase , telomere , mitochondrial respiratory chain , telomerase reverse transcriptase , biochemistry , dna , enzyme , rna , cytosol , gene

The enzyme telomerase and its catalytic subunit the telomerase reverse transcriptase (TERT) are important for maintenance of telomere length in the nucleus. Recent studies provided evidence for a mitochondrial localization of TERT. Therefore, we investigated the exact localization of TERT within the mitochondria and its function.

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