FXR Promotes Endothelial Cell Motility Through Coordinated Regulation of FAK and MMP-9 | Zendy

Amitava Das | Zendy; Usman Yaqoob | Zendy; Dolly Mehta | Zendy; Vijay H. Shah | Zendy

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FXR Promotes Endothelial Cell Motility Through Coordinated Regulation of FAK and MMP-9

Author(s) -

Amitava Das,

Usman Yaqoob,

Dolly Mehta,

Vijay H. Shah

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.182725

Subject(s) - motility , matrix metalloproteinase , microbiology and biotechnology , endothelial stem cell , cell , biology , cancer research , biochemistry , in vitro

Farnesoid X Receptor (FXR) mediates important signaling functions of bile acids in diverse cell types including those residing in the vascular wall. Indeed, recent work has identified FXR as a potential regulator of vascular structure and function in part through transcriptional activation of MMP-9. However, the signal transduction pathways linking bile acids to changes in actin cytoskeleton that are responsible for bile acid-induced vascular cell migration remain unexplored.

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