Mechanisms of Vascular Smooth Muscle NADPH Oxidase 1 (Nox1) Contribution to Injury-Induced Neointimal Formation
Author(s) -
Moo Yeol Lee,
Alejandra San Martín,
Puja K. Mehta,
Anna Dikalova,
Abel Martin Garrido,
Srinivasa Raju Datla,
Erin Lyons,
KarlHeinz Krause,
Botond Bánfi,
J. David Lambeth,
Bernard Lassègue,
Kathy K. Griendling
Publication year - 2009
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.181925
Subject(s) - nox1 , neointima , vascular smooth muscle , cofilin , cell migration , microbiology and biotechnology , chemistry , fibronectin , extracellular matrix , nadph oxidase , actin cytoskeleton , biology , cytoskeleton , cell , medicine , endocrinology , reactive oxygen species , biochemistry , restenosis , smooth muscle , stent
Vascular NADPH oxidases (Noxes) have been implicated in cardiovascular diseases; however, the importance of individual Nox homologues remains unclear. Here, the role of the vascular smooth muscle cell (VSMC) Nox1 in neointima formation was studied using genetically modified animal models.
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