Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells | Zendy

Niels Engberding | Zendy; Alejandra San Martín | Zendy; Abel Martín-Garrido | Zendy; Mitsuhisa Koga | Zendy; Lily Pounkova | Zendy; Erin Lyons | Zendy; Bernard Lassègue | Zendy; Kathy K. Griendling | Zendy

Open Access

Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells

Author(s) -

Niels Engberding,

Alejandra San Martín,

Abel Martín-Garrido,

Mitsuhisa Koga,

Lily Pounkova,

Erin Lyons,

Bernard Lassègue,

Kathy K. Griendling

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.181727

Subject(s) - insulin , medicine , endocrinology , receptor , growth factor , vascular smooth muscle , insulin like growth factor , insulin receptor , glucose uptake , biology , chemistry , smooth muscle , insulin resistance

Insulin resistance of vascular smooth muscle cells (VSMCs) has been linked to accelerated atherosclerosis in diabetes; however, the effects of insulin on VSMCs remain controversial. Most VSMC insulin receptors are sequestered into insulin-insensitive hybrids with insulin-like growth factor-1 receptors (IGF1Rs). Thus we hypothesized that regulation of IGF1R expression may impact cellular insulin sensitivity.

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