Early Growth Response-1 Regulates Angiopoietin-1-Induced Endothelial Cell Proliferation, Migration, and Differentiation | Zendy

Nelly Abdel-Karim Abdel-Malak | Zendy; Mahroo Mofarrahi | Zendy; Dominique Mayaki | Zendy; Levon M. Khachigian | Zendy; Sabah N. A. Hussain | Zendy

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Early Growth Response-1 Regulates Angiopoietin-1-Induced Endothelial Cell Proliferation, Migration, and Differentiation

Author(s) -

Nelly Abdel-Karim Abdel-Malak,

Mahroo Mofarrahi,

Dominique Mayaki,

Levon M. Khachigian,

Sabah N. A. Hussain

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.181073

Subject(s) - cell growth , microbiology and biotechnology , angiopoietin 2 , endothelial stem cell , angiogenesis , angiopoietin , biology , cancer research , immunology , vascular endothelial growth factor , vegf receptors , in vitro , genetics

Angiopoietin-1 (Ang-1) is an important regulator of angiogenesis in endothelial cells. It promotes migration, proliferation, and differentiation of cells, although the regulating factors involved in these processes remain unclear. In this study, we evaluated the contribution of the transcription factor early growth response-1 (Egr-1) to Ang-1-induced angiogenesis in human umbilical vein endothelial cells (HUVECs).

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