The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels | Zendy

Steven J.R. Meex | Zendy; Daphna WeissglasVolkov | Zendy; Carla Kallen | Zendy; Donna J. Thuerauf | Zendy; Marleen M. J. van Greevenbroek | Zendy; Casper G. Schalkwijk | Zendy; Coen D.A. Stehouwer | Zendy; Edith J. M. Feskens | Zendy; Lonneke Heldens | Zendy; Torik Ayoubi | Zendy; Marten H. Hofker | Zendy; Bradly G. Wouters | Zendy; Robert Vlietinck | Zendy; Janet S. Sinsheimer | Zendy; MarjaRiitta Taskinen | Zendy; Johanna Kuusisto | Zendy; Markku Laakso | Zendy; Tjerk W.A. de Bruin | Zendy; Päivi Pajukanta | Zendy; Christopher C. Glembotski | Zendy

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The ATF6-Met[67]Val Substitution Is Associated With Increased Plasma Cholesterol Levels

Author(s) -

Steven J.R. Meex,

Daphna WeissglasVolkov,

Carla Kallen,

Donna J. Thuerauf,

Marleen M. J. van Greevenbroek,

Casper G. Schalkwijk,

Coen D.A. Stehouwer,

Edith J. M. Feskens,

Lonneke Heldens,

Torik Ayoubi,

Marten H. Hofker,

Bradly G. Wouters,

Robert Vlietinck,

Janet S. Sinsheimer,

MarjaRiitta Taskinen,

Johanna Kuusisto,

Markku Laakso,

Tjerk W.A. de Bruin,

Päivi Pajukanta,

Christopher C. Glembotski

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.180240

Subject(s) - substitution (logic) , medicine , cholesterol , endocrinology , chemistry , computer science , programming language

Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes. We used a 2-stage design to investigate whether ATF6 polymorphisms are associated with lipids in subjects at increased risk for cardiovascular disease (CVD).

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