Open AccessVascular Endothelial Growth Factor
Author(s) -
Napoleone Ferrara
Publication year - 2009
Publication title -
arteriosclerosis, thrombosis, and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.108.179663
Subject(s) - angiogenesis , vascular endothelial growth factor , regulator , macular degeneration , vegf receptors , medicine , pathological , vascular endothelial growth factor a , cancer research , growth factor , biology , ophthalmology , receptor , biochemistry , gene
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.