Vascular Endothelial Growth Factor | Zendy

Napoleone Ferrara | Zendy

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Vascular Endothelial Growth Factor

Author(s) -

Napoleone Ferrara

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.179663

Subject(s) - angiogenesis , vascular endothelial growth factor , regulator , macular degeneration , vegf receptors , vascular endothelial growth factor a , medicine , pathological , cancer research , growth factor , biology , pathology , ophthalmology , receptor , biochemistry , gene

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.

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