Rab8 Regulates ABCA1 Cell Surface Expression and Facilitates Cholesterol Efflux in Primary Human Macrophages | Zendy

Matts D. Linder | Zendy; Mikko I. Mäyränpää | Zendy; Johan Peränen | Zendy; Taija E. Pietilä | Zendy; Vilja Pietiäinen | Zendy; RiikkaLiisa Uronen | Zendy; Vesa M. Olkkonen | Zendy; Petri T. Kovanen | Zendy; Elina Ikonen | Zendy

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Rab8 Regulates ABCA1 Cell Surface Expression and Facilitates Cholesterol Efflux in Primary Human Macrophages

Author(s) -

Matts D. Linder,

Mikko I. Mäyränpää,

Johan Peränen,

Taija E. Pietilä,

Vilja Pietiäinen,

RiikkaLiisa Uronen,

Vesa M. Olkkonen,

Petri T. Kovanen,

Elina Ikonen

Publication year - 2009

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.179481

Subject(s) - abca1 , efflux , microbiology and biotechnology , cell , cholesterol , chemistry , primary (astronomy) , expression (computer science) , biology , biochemistry , computer science , transporter , gene , physics , astronomy , programming language

ATP-binding cassette transporter A1 (ABCA1) is thought to lipidate apolipoprotein A-I (apoA-I) at the plasma membrane, with endosomal cholesterol contributing as substrate. The mechanisms of ABCA1 surface delivery are not well understood. We have shown that Rab8 regulates endosomal cholesterol removal to apoA-I in human fibroblasts. Here, we investigated whether Rab8 plays a role in ABCA1 plasma membrane expression and cholesterol removal in primary human macrophages.

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