Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells | Zendy

Marpadga A. Reddy | Zendy; Saurabh Sahar | Zendy; Louisa M. Villeneuve | Zendy; Linda Lanting | Zendy; Rama Natarajan | Zendy

Open Access

Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells

Author(s) -

Marpadga A. Reddy,

Saurabh Sahar,

Louisa M. Villeneuve,

Linda Lanting,

Rama Natarajan

Publication year - 2008

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.108.179150

Subject(s) - proto oncogene tyrosine protein kinase src , vascular smooth muscle , tyrosine kinase , chromatin immunoprecipitation , histone h3 , signal transduction , biology , microbiology and biotechnology , lipid signaling , chemistry , histone , gene expression , biochemistry , endocrinology , promoter , receptor , smooth muscle , gene

The 12/15-Lipoxygenase (12/15-LO) and its metabolite 12(S)-Hydroxyeicosatetraenoic acid [12(S)-HETE] mediate proatherogenic responses in vascular smooth muscle cells (VSMCs). We examined the role of the nonreceptor tyrosine kinase Src in the signaling and epigenetic chromatin mechanisms involved in these processes.

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